Water → HCID 67520875, compound

Participants

Reaction Steps

Synthesized as described for 7 using 6 (300.0 mg, 0.65 mmol), cesium carbonate (634.0 mg; 1.95 mmol), (E)-2-(3-methoxyprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxoborolane (193.0 mg; 0.97 mmol), tetrakis(triphenylphosphine)palladium(0) (37.0 mg; 0.032 mmol), toluene (1.5 mL), water (1.5 mL) and ethanol (1.5 mL). The crude dark oil was purified by automated silica gel column chromatography (Biotage®) eluting with ethyl acetate/hexanes (0 to 20% v/v gradient elution over 500 mL) to give the title compound as a yellow oil (189 mg).

Provenance & Evidence