HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylbenzylamine → HCID 10976320, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | 1-Bromopentane | HCID 8057 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 86645229 | HCID 86645229 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 10976320 | HCID 10976320 | — |
Reaction Steps
The present invention provides an alternate process for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III) wherein N-methyl benzyl amine is condensed with 1-bromo pentane in presence of potassium carbonate, using acetone as solvent to give N-methyl N-pentyl benzyl amine. This is debenzylated using palladium on carbon as catalyst and alcohol as solvent. The resulting product N-methyl pentyl amine is condensed with methyl acrylate in toluene to get 3-[N-(methylpentyl)amino]propionate, which is further hydrolysed to obtain Intermediate III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178712B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ca97add7c0924b36a4e84c798bc19062 |
| Source note | uspto-grants-2012_05 |