Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | 5-Methyl hydrogen L-glutamate | HCID 68662 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | L-Theanine | HCID 439378 | 29.6% |
Reaction Steps
First, 5.0 g (31 mmol) of L-glutamic acid-γ-methyl ester was suspended in 15 mL of methanol. To this, 3.4 g (34 mmol) of acetylacetone, 1.9 g (31 mmol) of acetic acid, and 5.0 g of anhydrous sodium sulfate were added. The mixture was heated at 60° C. for 2 hours. Subsequently, sodium sulfate was filtrated off. To the filtrate, 20 g (310 mmol) of 70% ethylamine was added and the same procedure as in Example 1 was performed to obtain 1.6 g of theanine (yield: 29.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08178722B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-e51dab4b45b841bcaa22c2b1db0a5a6e |
|---|
| Source note | uspto-grants-2012_05 |
|---|
