Carbon tetrabromide → HCID 67521426, compound

Participants

Reaction Conditions

Reaction Steps

To an ice-cooled mixture of 3-Hydroxymethyl-2H-chromene-2-carboxylic acid ethyl ester (1.73 g, 7.39 mmol) in methylene chloride (25 mL) was added commercially available carbon tetrabromide (2.70 g, 8.13 mmol) and commercially available triphenylphosphine (1.94 g, 7.39 mmol). After addition was complete the mixture was stirred at 0° C. for 6 hours. Upon completion of the reaction, the methylene chloride was removed under reduced pressure. The crude product obtained was purified by ISCO flash chromatography (Teledyne Isco RediSep Flash Column 40 g; (0% to 90% ethyl acetate/hexane) to afford 3-bromomethyl-2H-chromene-2-carboxylic acid ethyl ester as a yellow oil, 1.08 g (49% yield).

Provenance & Evidence