HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(2-pyridylmethoxy)aniline → N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-(2-ethoxyethyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(2-pyridylmethoxy)aniline | HCID 16781212 | — |
| Reactant | 4-chloro-5-(2-ethoxyethyl)-5H-pyrrolo[3,2-d]pyrimidine | HCID 86084822 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-(2-ethoxyethyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine | HCID 57597275 | 53.2% |
Reaction Steps
To a solution of 4-chloro-5-(2-ethoxyethyl)-5H-pyrrolo[3,2-d]pyrimidine (160 mg) in 1-methyl-2-pyrrolidone (1.4 mL) was added 3-chloro-4-(pyridin-2-ylmethoxy)aniline (250 mg). The title compound (160 mg) was obtained as pale-yellow needle crystals by the reaction in the same manner as in Example 42 (ii).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178543B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-63ae6a192c114970a96a5b87099b6735 |
| Source note | uspto-grants-2012_05 |