Hydrochloric Acid → 2-(2-(9H-fluoren-9-ylidene)acetamido)acetic acid

Participants

Reaction Steps

2-(2-(9H-fluoren-9-ylidene)acetamido)acetic acid methyl ester (293 mg, 1 mmol) and 300 ml of CH3OH were stirred at room temperature while 25 ml of 4 N solution of LiOH in H2O was added. The mixture was stirred for 5 hours at room temperature. The mixture is neutralized with concentrated hydrochloric acid to pH 7 and evaporated under vacuum to remove methanol. The residue was adjusted to pH 3 with concentrated hydrochloric acid. The solids were collected by vacuum filtration, washed with water and dried under vacuum to give the title compound (259 mg, 93% yield) as a white solid. LC-MS (m/z) 280 (M+1).

Provenance & Evidence