反应详情

To a solution of 4-{4-[6-Amino-5-(1-methylisoquinolin-3-yl)-pyridin-3-yl]-pyrazol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester (36.8 mg, 0.0759 mmol) in 1,4-dioxane (1.0 mL, 13 mmol) was added 4.0 M of HCl in 1,4-dioxane (1.0 mL, 4.0 mmol), and the mixture was stirred at ambient temperature for 1.5 h. Almost immediately a pale yellow solid precipitated. The solid was filtered off, washed with MTBE, and dried in vacuo, giving the title compound as pale yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=14.7 (very brs, 1H), 9.33-9.23 (brm, 1H), 9.21-9.08 (brm, 1H), 8.82 (d, J=1.8 Hz, 1H), 8.8 (very brs, 2H), 8.59 (s, 1H), 8.50 (s, 1H), 8.48 (d, J=1.8 Hz, 1H), 8.38 (d, J=8.4 Hz, 1H), 8.14 (s, 1H), 8.13 (d, J=8.0 Hz, 1H), 7.95 (dd, J=7.2, 7.2 Hz, 1H), 7.84 (dd, J=7.8, 7.8 Hz, 1H), 4.58-4.49 (mc, 1H), 3.39 (brd, J=12.6 Hz, 2H), 3.11 (brq, J=11.4 Hz, 2H), 3.07 (s, 3H), 2.30-2.13 (m, 4H). MS(ES+): m/z=385.15 (53) [MH+], 302.12 (100) [MH+-piperidine]. HPLC: tR=1.88 min (polar—5 min, ZQ3).

1. customAlmost immediately a pale yellow solid precipitated
2. filtrationThe solid was filtered off
3. washwashed with MTBE
4. customdried in vacuo