N-(2-bromobenzyl)-2,2-dimethoxyacetamide → HCID 178515316, compound

HRID 1926274Notes

Reaction equation

HRID 1926274 reaction equation
BrC1C=CC=C2C=1C=C(O)N=C2.BrC1C=C2C(C=C(O)N=C2)=CC=1.[Br:25][C:26]1[CH:40]=[CH:39][CH:38]=[CH:37][C:27]=1[CH2:28][NH:29][C:30](=[O:36])[CH:31](OC)OC>>[Br:25][C:26]1[CH:40]=[CH:39][CH:38]=[C:37]2[C:27]=1[CH:28]=[N:29][C:30]([OH:36])=[CH:31]2

Participants

4

Reactant 3

HCID 67520920N-(2-bromobenzyl)-2,2-dimethoxyacetamideHCID 178515296HCID 178515296, compoundHCID 178515312HCID 178515312, compound

Product 1

HCID 178515316HCID 178515316, compound

Procedure

The title compounds was obtained as a yellow solid following the procedure for 5-bromoisoquinolin-3-ol and 7-bromoisoquinolin-3-ol, using N-(2-bromobenzyl)-2,2-dimethoxyacetamide. MS (ES+): m/z=224.04/226.03 [MH+]. HPLC: tR=2.39 min (ZQ2, polar—5 min).

Workup

  1. customHPLC: tR=2.39 min (ZQ2, polar—5 min)

Sources & evidence

ORD record
ord-29582883d4fa4410af9f8f504336f208
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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