Dimethylformamide → HCID 67520980, compound

Participants

Reaction Steps

Following the General Procedure for Conversion of Bromo(het)aryl to Cyano(het)aryl, 4-{4-[6-amino-5-(6-bromoisoquinolin-3-yl)-pyridin-3-yl]-pyrazol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester (220 mg, 0.240 mmol) was reacted with Pd(PPh3)4 (38.9 mg, 0.0336 mmol) and zinc cyanide (28.2 mg, 0.240 mmol) in DMF (6 ml). The crude product was purified by chromatography on silica gel (8 g) eluting with DCM (100 ml), 1% (100 ml), 2% (100 ml), 3% (100 ml) and 4% (50 ml) MeOH/DCM to give the title compound as a yellow solid. MS(ES+): m/z=496.22 (100) [MH+]. HPLC: tR=2.82 min (ZQ3, polar—5 min).

Provenance & Evidence