Sulfuric Acid → HCID 178515344, compound

Participants

Reaction Conditions

Reaction Steps

Into a RBF was added N-(3-Fluorobenzyl)-2,2-dimethoxyacetamide (1.53 g, 6.73 mmol) and sulfuric acid (18M; 3.4 mL, 61 mmol); this mixture was stirred at 85° C. for 5 min. Ice water was added and stirred, and then solid NaHCO3 was carefully added until the solution was neutralized. The aqueous layer was extracted with DCM. The DCM layer was dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound. It was carried onto the next step without any further purification. HPLC: tR=2.13 min. (ZQ2, polar—5 min.). MS (ES+): m/z=164.69 (100) [MH+].

Provenance & Evidence