Acetic acid, 2,2-dimethoxy-, methyl ester → HCID 67521398, compound

Participants

Reaction Conditions

Reaction Steps

Into a sealable tube were added methyl dimethoxyacetate (0.98 g, 7.3 mmol) and 3-fluorobenzylamine (0.91 g, 7.3 mmol); this mixture was stirred at 60° C. for 2 days. The compound was purified by chromatography on silica gel (10 g/70 mL prepacked column, eluting with 5% EtOAc in hexanes→5% MeOH in hexanes), affording the title compound. HPLC: tR=2.59 min. (ZQ2, polar—5 min.). MS (ES+): m/z=249.92 (29) [MNa+], 227.91 (100) [MH+].

Provenance & Evidence