Sulfuric Acid → HCID 178515366, compound

Participants

Reaction Conditions

Reaction Steps

Into a RBF were added N-(4-Fluorobenzyl)-2,2-dimethoxyacetamide (1.53 g, 6.73 mmol) and sulfuric acid (18M; 3.4 mL, 61 mmol). This mixture was stirred at 85° C. for 5 min. Ice water was added and stirred; then solid NaHCO3 was added until the pH was 7-8. This was allowed to stir, then DCM was added and stirred to dissolve product. A solid precipitated out of the solution after 16 h. It was filtered off and dried in vacuo to give the title compound as yellow solid. HPLC: tR=2.07 min. (ZQ2, polar—5 min.). MS (ES+): m/z 164.24 (100) [MH+].

Provenance & Evidence