HCID 67520446, compound → 3-[2-Amino-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)-pyridin-3-yl]-isoquinoline-8-carbonitrile trihydrochloride salt

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The procedure for the preparation of 3-(5,8-dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride was followed, except using trifluoromethanesulfonic acid 8-cyanoisoquinolin-3-yl ester in place of trifluoromethanesulfonic acid 5,8-dichloroisoquinolin-3-yl ester. This afforded the title compound as a yellow solid. 1H NMR (400 MHz, CD3OD): δ=2.30-2.42 (m, 4H), 3.21-3.27 (m, 2H), 3.59 (d, J=13.4 Hz, 2H), 4.59-4.71 (m, 1H), 7.97-8.04 (m, 1H), 8.08 (s, 1H), 8.25-8.30 (m, 2H), 8.42-8.49 (m, 2H), 8.86 (s, 1H), 8.93 (d, J=2.0 Hz, 1H), 9.70 (s, 1H). MS (ES+): m/z=396.19 [MH+]. HPLC: tR=1.67 min (ZQ2, polar—5 min).

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