Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester → HCID 86633148, compound

HRID 1926286Notes

Reaction equation

HRID 1926286 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:5]2.O[C:21]1[N:22]=CC2C(C=1)=CC=CC=2C#N>>[C:21]([C:10]1[CH:11]=[CH:2][CH:3]=[C:4]2[C:9]=1[CH:8]=[N:7][C:6]([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:5]2)#[N:22]

Participants

3

Reactant 2

HCID 86633147Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl esterHCID 178509591HCID 178509591, compound

Product 1

HCID 86633148HCID 86633148, compound

Procedure

Following the procedure for trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester, using 3-hydroxyisoquinoline-8-carbonitrile in place of 6-fluoroisoquinolin-3-ol, the title compound was obtained as a yellow solid. MS (ES+): m/z=303.04 [MH+]. HPLC: tR=3.55 min (ZQ2, polar—5 min).

Sources & evidence

ORD record
ord-a2b3f5b44fde4e71b2dcbb01a91a3564
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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