HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester → Trifluoromethanesulfonic acid 5-cyano-8-fluoroisoquinolin-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester | HCID 86633147 | — |
| Reactant | 8-Fluoro-3-hydroxyisoquinoline-5-carbonitrile | HCID 178509890 | — |
| Product | Trifluoromethanesulfonic acid 5-cyano-8-fluoroisoquinolin-3-yl ester | HCID 86633149 | — |
Reaction Steps
Following the procedure for trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester, using 8-fluoro-3-hydroxyisoquinoline-5-carbonitrile in place of 6-fluoroisoquinolin-3-ol, the title compound was obtained as a yellow solid. MS (ES+): m/z=321.06 [MH+]. HPLC: tR=3.58 min (ZQ2, polar—5 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2ca2515d5ffd481c84c81e41788584f0 |
| Source note | uspto-grants-2012_05 |