Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester → Trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester

HRID 1926293Notes

Reaction equation

HRID 1926293 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:5]2.[Cl:20]C1C=C2C(=CC=1)C=NC(O)=C2>>[Cl:20][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:5]2

Participants

3

Reactant 2

HCID 86633147Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl esterHCID 178515347HCID 178515347, compound

Product 1

HCID 86633150Trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester

Procedure

Following the procedure for trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester, using 6-chloroisoquinolin-3-ol in place of 6-fluoroisoquinolin-3-ol, the title compound was obtained as a yellow solid. MS (ES+): m/z=311.69/313.63 [MH+]. HPLC: tR=3.88 min (ZQ2, polar—5 min).

Sources & evidence

ORD record
ord-bb056821ebcc49efb303da95b749a89c
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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