HCID 67520446, compound → 3-(7-Chloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride

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The procedure for the preparation of 3-(5,8-dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride was followed, except using trifluoromethanesulfonic acid 7-chloroisoquinolin-3-yl ester in place of trifluoromethanesulfonic acid 5,8-dichloroisoquinolin-3-yl ester. This afforded the title compound as a yellow solid. 1H NMR (400 MHz, CD3OD): δ=2.29-2.46 (m, 4H), 3.24-3.31 (m, 2H), 3.59-3.67 (m, 2H), 4.61-4.72 (m, 1H), 7.91 (dd, J=8.8, 2.0 Hz 1H), 8.10 (s, 1H), 8.18 (d, J=9.0 Hz, 1H), 8.28 (d, J=2.0 Hz, 1H), 8.30 (d, J=2.0 Hz, 1H), 8.43 (s, 1H), 8.73 (s, 1H), 8.90 (d, J=2.3 Hz, 1H), 9.43 (s, 1H). MS (ES+): m/z=405.09/407.03 [MH+]. HPLC: tR=1.95 min (ZQ3, polar—5 min).

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