HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67520446, compound → 3-(5-Chloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67520446 | HCID 67520446 | — |
| Reactant | Trifluoromethanesulfonic acid 5-chloroisoquinolin-3-yl ester | HCID 86633152 | — |
| Product | 3-(5-Chloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride | HCID 67521312 | — |
Reaction Steps
The procedure for the preparation of 3-(5,8-dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride was followed, except using trifluoromethanesulfonic acid 5-chloroisoquinolin-3-yl ester in place of trifluoromethanesulfonic acid 5,8-dichloroisoquinolin-3-yl ester. This afforded the title compound as a yellow solid. MS (ES+): m/z=405.05/407.03 [MH+]. HPLC: tR=1.91 min (ZQ2, polar—5 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-18e73aefffff4ce08aa324b1478682fe |
| Source note | uspto-grants-2012_05 |