HCID 67520446, compound → 3-(6,8-Dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride

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The procedure for the preparation of 3-(5,8-dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride was followed, except using trifluoromethanesulfonic acid 6,8-dichloroisoquinolin-3-yl ester in place of trifluoromethanesulfonic acid 5,8-dichloroisoquinolin-3-yl ester. This afforded the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.31 (m, 4H), 3.04-3.18 (m, 2H), 3.33-3.46 (m, 2H), 4.45-4.59 (m, 1H). 8.11 (d, J=1.8 Hz, 1H), 8.14 (s, 1H), 8.22 (d, J=1.3 Hz, 1H), 8.48 (d, J=2.0 Hz, 1H), 8.50 (s, 1H), 8.63 (br. s., 1H), 8.75 (s, 1H), 8.83 (d, J=2.0 Hz, 1H), 8.95 (br. s., 1H), 9.07 (br. s., 1H), 9.65 (s, 1H). MS (ES+): m/z=439.07/441.07/443.06 [MH+]. HPLC: tR=2.00 min (ZQ2, polar—5 min).

Provenance & Evidence