2,4-Dichlorobenzylamine → N-(2,4-Dichlorobenzyl)-2,2-dimethoxyacetamide

Participants

Reaction Conditions

Reaction Steps

Into a sealed tube were added methyl dimethoxyacetate (0.78 g, 5.8 mmol) and 2,4-dichlorobenzylamine (1.0 g, 5.8 mmol). This mixture was stirred at 50° C. for 36 h. The completed reaction mixture was transferred to a flask and re-crystallized from heptane yielding the desired product as an off-white solid. MS (ES+): m/z=278.10/280.09/282.08 [MH+]. HPLC: tR=3.03 min (ZQ2, polar—5 min).

Provenance & Evidence