HCID 67520446, compound → HCID 67520961, compound

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The procedure for the preparation of 3-(5,8-dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride was followed, except using trifluoromethanesulfonic acid 7-methoxyisoquinolin-3-yl ester in place of trifluoromethanesulfonic acid 5,8-dichloroisoquinolin-3-yl ester. This afforded the title compound as a yellow solid. 1H NMR (400 MHz, CD3OD): δ=2.32-2.44 (m, 4H), 3.23-3.31 (m, 2H), 3.58-3.67 (m, 2H), 4.08 (s, 3H), 4.61-4.72 (m, 1H), 7.67-7.74 (m, 2H), 8.08 (s, 1H), 8.16 (d, J=8.8 Hz, 1H), 8.31 (d, J=2.0 Hz, 1H), 8.40 (s, 1H), 8.65 (s, 1H), 8.79 (d, J=2.0 Hz, 1H), 9.51 (s, 1H). MS (ES+): m/z=401.14 [MH+]. HPLC: tR=1.88 min (ZQ3, polar—5 min).

Provenance & Evidence