HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxybenzylamine → 2,2-Dimethoxy-N-[(3-methoxyphenyl)methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxybenzylamine | HCID 21156 | — |
| Reactant | Acetic acid, 2,2-dimethoxy-, methyl ester | HCID 66647 | — |
| Product | 2,2-Dimethoxy-N-[(3-methoxyphenyl)methyl]acetamide | HCID 21419366 | — |
Reaction Steps
Into a vial was added methyl dimethoxyacetate (2.0 g, 14 mmol) and 3-methoxybenzylamine (2.0 g, 14 mmol), this mixture was stirred at room temperature for 8 d. The product was triturated with heptane (3×) and then dried in vacuo, yielding the desired product as an off-white solid. MS (ES+): m/z=240.84 [MH+]. HPLC: tR=2.55 min (ZQ2, polar—5 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2aecf0ab3cf046d8b2f8457f629bff99 |
| Source note | uspto-grants-2012_05 |