HCID 67520446, compound → HCID 67520858, compound

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The procedure for the preparation of 3-(5,8-dichloroisoquinolin-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine trihydrochloride was followed, except using trifluoromethanesulfonic acid 6-methoxyisoquinolin-3-yl ester in place of trifluoromethanesulfonic acid 5,8-dichloroisoquinolin-3-yl ester. This afforded the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.16-2.29 (m, 4H), 3.05-3.17 (m, 2H), 3.38 (d, J=12.6 Hz, 2H), 4.00 (s, 3H), 4.48-4.59 (m, 1H), 7.46-7.54 (m, 2H), 8.13 (s, 1H), 8.27 (d, J=8.8 Hz, 1H), 8.48-8.51 (m, 2H), 8.59 (s, 1H), 8.80 (d, J=2.3 Hz, 1H), 9.19 (br. s., 1H), 9.28 (br. s., 1H), 9.45 (s, 1H). MS (ES+): m/z=318.16 [MH+]. HPLC: tR=1.70 min (ZQ2, polar—5 min).

Provenance & Evidence