Acetone → HCID 21541262, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of (4-methoxyphenyl)acetyl chloride (0.500 g, 2.71 mmol) in acetone (1.0 mL) at 0° C. was added a solution of formamide (0.28 mL, 7.0 mmol) and pyridine (0.28 mL, 3.5 mmol) in acetone (1.0 mL). The resulting solution was stirred at 0° C. for 30 min and then overnight at rt. The reaction mixture was diluted with EtOAc and washed with 1M HCl, sat. NaHCO3 solution, brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude material was purified by column chromatography eluting with 1% MeOH in DCM yielding the title compound as an off-white solid. MS (ES+): m/z=194.11 [MH+]. HPLC: tR=2.57 min (ZQ3, polar—5 min).

Provenance & Evidence