Hydrochloric Acid → 3-(5-Chloro-8-fluoroisoquinolin-3-yl)-5-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-2-ylamine trihydrochloride

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Reaction Steps

To a solution of 3-(5-Chloro-8-fluoroisoquinolin-3-yl)-5-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-2-ylamine (25 mg, 0.057 mmol) in DCM (2.8 mL) was added 1.0 M of HCl in Et2O (2.8 mL, 2.8 mmol), causing a solid to precipitate. The solid was filtered off, washed with DCM and heptane, and dried in vacuo, yielding the title compound as yellow solid. 1H NMR (400 MHz, CD3OD): δ=2.36-2.47 (m, 4H), 3.67-3.76 (m, 2H), 4.19-4.24 (m, 1H), 4.58-4.69 (m, 1H), 4.70 (s, 1H), 7.47-7.54 (m, 1H), 8.00 (dd, J=8.3, 4.8 Hz, 1H), 8.05-8.09 (m, 1H), 8.29 (s, 1H), 8.38 (s, 1H), 8.71 (s, 1H), 8.83 (s, 1H), 9.68 (s, 1H).

Provenance & Evidence