Hydrochloric Acid → HCID 67520828, compound

Participants

Reaction Steps

A solution of 3-benzofuran-2-yl-5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-ylamine (60 mg, 0.207 mmol) in dioxane (3 mL) was charged with 4.0 M of HCl in dioxane (1 mL) at rt. Upon addition, a solid precipitated and all solvent was removed in vacuo. MeOH and heptane were added and the solid was filtered off and dried, giving the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=3.89 (s, 3H), 7.31-7.38 (m, 1H), 7.43 (ddd, J=8.3, 7.1, 1.3 Hz, 1H), 7.64 (d, J=0.8 Hz, 1H), 7.71 (dd, J=8.2, 0.6 Hz, 1H), 7.77 (dd, J=7.8, 0.5 Hz, 1H), 8.02 (d, J=0.5 Hz, 1H), 8.32 (s, 1H), 8.42 (d, J=2.0 Hz, 1H), 8.64 (d, J=2.3 Hz, 1H). MS (ES+): m/z=291.07 (100) [MH+]. HPLC: tR=2.67 min (ZQ3, polar—5 min).

Provenance & Evidence