2-Chlorobenzothiazole → HCID 67521387, compound

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Reaction Steps

The procedure for 3-benzoxazol-2-yl-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine dihydrochloride except using 2-chlorobenzothiazole in place of 2-chlorobenzoxazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.22 (m, 2H), 2.27 (d, J=13.5 Hz, 2H), 3.07-3.18 (m, 2H), 3.43 (d, J=13.2 Hz, 2H), 4.47-4.57 (m, 1H), 7.50 (t, J=7.5 Hz, 1H), 7.55-7.61 (m, 1H), 8.02 (s, 1H), 8.10 (d, J=8.0 Hz, 1H), 8.16 (d, J=7.7 Hz, 1H), 8.21 (br. s., 1H), 8.33 (s, 1H), 8.50 (d, J=2.2 Hz, 1H). MS (ES+): m/z=376.80 [MH+]. HPLC: tR=2.02 min (ZQ2, polar—5 min).

Provenance & Evidence