反应详情

The title compound was prepared following the procedure for 3-(5-chloro-8-fluoroisoquinolin-3-yl)-pyridin-2-ylamine, using 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine (30.0 g, 136 mmol), 2-chlorobenzothiazole (16.5 g, 97 mmol), Pd(PPh3)4 (3.3 g, 3 mol %), and Cs2CO3 (72.6 g, 223 mmol). 1H NMR (CDCl3, 300 MHz): δ=6.71 (dd, J=6.8, 3.6 Hz, 1H), 7.13 (brs, 2H), 7.38 (t, J=8.4 Hz, 1H), 7.47 (t, J=8.4 Hz, 1H), 7.87 (d, J=6.0 Hz, 1H), 7.95 (dd, J=6.2, 1.5 Hz, 1H), 7.99 (d, J=6.0 Hz, 1H), 8.18 (dd, J=6.2, 1.2 Hz, 1H).