反应详情

Following the procedure for 4-(6-Amino-5-benzothiazol-2-ylpyridin-3-yl)-benzoic acid methyl ester, the title compound was prepared from 3-benzothiazol-2-yl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine (BB8) (1.41 g, 4.0 mmol), 4-iodopyridine-2-carboxylic acid methyl ester (0.85 g, 3.2 mmol), Pd(PPh3)4 (2 mol %) and Cs2CO3 (2.5 g, 7.7 mmol) in dioxane/water (5:1; 18 mL). 1H NMR (CD3OD, 300 MHz): δ=4.01 (s, 3H), 7.38-7.45 (m, 2H), 7.70 (dd, J=7.2, 2.4 Hz, 1H), 7.85 (d, J=6.8 Hz, 1H), 7.95 (d, J=6.8 Hz, 1H), 8.21 (d, J=2.4 Hz, 1H), 8.31 (d, J=2.4 Hz, 1H), 8.44 (d, J=2.4 Hz, 1H), 8.70 (d, J=7.2 Hz, 1H).