Trifluoroacetic acid → HCID 67521016, compound

Participants

Reaction Steps

The procedure for 5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-3-[7-(1H-pyrazol-4-yl)benzothiazol-2-yl]pyridin-2-ylamine dihydrochloride was followed, except that TFA in DCM was used for removing the Boc group. 1H NMR (400 MHz, CD3OD): δ=2.24-2.43 (m, 4H), 3.19-3.29 (m, 2H), 3.60 (d, J=13.1 Hz, 2H), 4.60 (ddd, J=10.2, 5.3, 5.2 Hz, 1H), 6.66 (q, J=2.5 Hz, 1H), 6.92 (q, J=2.7 Hz, 1H), 7.28-7.36 (m, 1H), 7.55 (t, J=7.8 Hz, 1H), 7.59-7.65 (m, 1H), 7.86-7.93 (m, 1H), 8.00 (s, 1H), 8.19-8.31 (m, 2H), 8.57 (d, J=2.0 Hz, 1H), 10.76 (br. s., 1H). MS (ES+): m/z=442.19 (100) [MH+]. HPLC: tR=2.38 min (ZQ3, polar—5 min).

Provenance & Evidence