反应详情

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2,6-dichloro-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.30 (m, 4H), 3.06-3.18 (m, 2H), 3.41 (d, J=13.2 Hz, 2H), 4.52 (ddd, J=14.8, 10.6, 4.2 Hz, 1H), 7.62 (dd, J=8.8, 1.8 Hz, 1H), 8.05 (s, 1H), 8.12 (d, J=8.8 Hz, 1H), 8.31 (br. s., 1H), 8.37 (br. s., 2H), 8.53 (s, 1H). MS (ES+): m/z=411.08 [MH+]. HPLC: tR=2.30 min (ZQ2, polar—5 min).