反应详情

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-6-methyl-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.31 (m, 4H), 3.12 (q, J=10.6 Hz, 2H), 3.42 (d, J=12.4 Hz, 2H), 4.47-4.57 (m, 1H), 7.41 (d, J=6.9 Hz, 1H), 7.96-8.02 (m, 2H), 8.05 (s, 1H), 8.31 (br. s., 1H), 8.38 (s, 1H), 8.49 (d, J=2.2 Hz, 1H). MS (ES+): m/z=391.15 [MH+]. HPLC: tR=2.22 min (ZQ2, polar—5 min).