反应详情

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-6-methoxy-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.30 (m, 4H), 3.04-3.17 (m, 2H), 3.41 (d, J=12.8 Hz, 2H), 3.89 (s, 3H), 4.48-4.59 (m, 1H), 7.20 (dd, J=9.1, 2.5 Hz, 1H), 7.78 (d, J=2.5 Hz, 1H), 8.03 (d, J=9.1 Hz, 1H), 8.08 (s, 1H), 8.38-8.45 (m, 2H), 8.50 (d, J=2.0 Hz, 1H). MS (ES+): m/z=407.12 [MH+]. HPLC: tR=2.13 min (ZQ2, polar—5 min).