2-Chloro-4-fluorobenzothiazole → 3-(4-Fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

Participants

Reaction Steps

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-4-fluoro-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.11-2.22 (m, 2H), 2.23-2.31 (m, 2H), 3.06-3.18 (m, 2H), 3.42 (d, J=12.1 Hz, 2H), 4.48-4.57 (m, 1H), 7.42-7.49 (m, 1H), 7.50-7.57 (m, 1H), 8.00-8.07 (m, 2H), 8.30 (br. s., 1H), 8.37 (br. s., 1H), 8.54 (s, 1H). MS (ES+): m/z=395.12 [MH+]. HPLC: tR=2.05 min (ZQ2, polar—5 min).

Provenance & Evidence