2,5-Dichloro-1,3-benzothiazole → HCID 44158820, compound

Participants

Reaction Steps

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2,5-dichloro-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.22 (m, 2H), 2.22-2.30 (m, 2H), 3.12 (q, J=11.1 Hz, 2H), 3.42 (d, J=12.4 Hz, 2H), 4.47-4.55 (m, 1H), 7.56 (d, J=8.4 Hz, 1H), 8.03 (s, 1H), 8.19-8.24 (m, 2H), 8.26 (br. s., 1H), 8.35 (s, 1H), 8.52 (s, 1H), MS (ES+): m/z=411.09/413.10 (3:1) [MH+]. HPLC: tR=2.18 min (ZQ2, polar—5 min).

Provenance & Evidence