HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1926392Generated: November 2, 2026
2-Fluoro-5-(trifluoromethyl)aniline → 2-Chloro-5-(trifluoromethyl)-1,3-benzothiazole
https://huagongshe.com/reaction/1926392
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Fluoro-5-(trifluoromethyl)aniline | HCID 136349 | — |
| Reactant | 2,5-Dichloro-1,3-benzothiazole | HCID 13314816 | — |
| Reactant | 5-(trifluoromethyl)-1,3-benzothiazole-2-thiol | HCID 178419087 | — |
| Product | 2-Chloro-5-(trifluoromethyl)-1,3-benzothiazole | HCID 21985849 | — |
Reaction Steps
The title compound was prepared from 2-fluoro-5-trifluoromethylaniline via 2-mercapto-5-trifluoromethyl-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 95° C. for 4 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178668B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-cb179b5601b245b6b12255b4d7b86bd6 |
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| Source note | uspto-grants-2012_05 |
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