2-Chloro-7-methyl-1,3-benzothiazole → 3-(7-Methylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

Participants

Reaction Steps

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-7-methyl-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.11-2.31 (m, 4H), 2.61 (s, 3H), 3.12 (q, J=11.8 Hz, 2H), 3.42 (d, J=12.8 Hz, 2H), 4.46-4.56 (m, 1H), 7.36 (d, J=7.3 Hz, 1H), 7.52 (t, J=7.7 Hz, 1H), 7.97 (d, J=8.0 Hz, 1H), 8.07 (s, 1H), 8.43 (br. s., 2H), 8.52 (s, 1H). MS (ES+): m/z=391.16 [MH+]. HPLC: tR=2.24 min (ZQ2, polar—5 min).

Provenance & Evidence