2-Chloro-7-methoxybenzo[d]thiazole → HCID 44158933, compound

Participants

Reaction Steps

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-7-methoxy-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, CD3OD): δ=8.80 (d, J=2.0 Hz, 1H), 8.38 (s, 1H), 8.35 (d, J=2.0 Hz, 1H), 8.07 (s, 1H), 7.79 (d, J=8.0 Hz, 1H), 7.59 (m, 1H), 7.13 (d, J=7.6 Hz, 1H), 4.66 (m, 1H), 4.06 (s, 3H), 3.59-3.62 (m, 2H), 2.33-2.39 (m, 4H). MS(ES+): m/z=407.13 [MH+]. HPLC: tR=1.78 min (polar—5 min, ZQ3).

Provenance & Evidence