HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-bromobenzothiazole → HCID 44158934, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-bromobenzothiazole | HCID 2049865 | — |
| Reactant | 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine | HCID 67521015 | — |
| Product | HCID 44158934 | HCID 44158934 | — |
Reaction Steps
Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 4-bromo-2-chloro-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, CD3OD): δ=8.81 (s, 1H), 8.44 (s, 1H), 8.41 (s, 1H), 8.11 (d, J=8.0 Hz, 1H), 8.08 (s, 1H), 7.84 (d, J=8.0 Hz, 1H), 7.47 (t, J=8.0 Hz, 1H), 4.68 (m, 1H), 3.59-3.63 (m, 2H), 2.38-2.41 (m, 4H). MS(ES+): m/z=455.01/456.92 [MH+]. HPLC: tR=1.59 min (polar—5 min, ZQ3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8bd00969161f4f639522115fa3fb5e4e |
| Source note | uspto-grants-2012_05 |