2,6-Dibromoaniline → 2-Chloro-4-bromobenzothiazole

HRID 1926400Notes

Reaction equation

HRID 1926400 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5](Br)[C:3]=1[NH2:4].BrC1C2N=C(S)SC=2C=CC=1.[Cl:21][C:22]1[S:23]C2C=CC(Cl)=CC=2N=1>>[Br:1][C:2]1[C:3]2[N:4]=[C:22]([Cl:21])[S:23][C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 690982,6-DibromoanilineHCID 133148162,5-Dichloro-1,3-benzothiazoleHCID 178527748HCID 178527748, compound

Product 1

HCID 20498652-Chloro-4-bromobenzothiazole

Conditions

Temperature
150 °C

Procedure

The title compound was prepared from 2,6-dibromoaniline via 4-bromo-2-mercapto-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 150° C. for 16 h.

Sources & evidence

ORD record
ord-10c1aa0c999e440ca96c948f5cf34778
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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