2,5-Dichloro-1,3-benzothiazole → 2-Chloro-7-fluoro-4-trifluoromethyl-1,3-benzothiazole

HRID 1926408Notes

Reaction equation

HRID 1926408 reaction equation
F[C:2]1[C:8]([F:9])=[CH:7][CH:6]=[C:5]([C:10]([F:13])([F:12])[F:11])[C:3]=1[NH2:4].SC1SC2C(F)=CC=C(C(F)(F)F)C=2N=1.[Cl:29][C:30]1[S:31]C2C=CC(Cl)=CC=2N=1>>[Cl:29][C:30]1[S:31][C:2]2[C:8]([F:9])=[CH:7][CH:6]=[C:5]([C:10]([F:13])([F:12])[F:11])[C:3]=2[N:4]=1

Participants

4

Reactant 3

HCID 133148162,5-Dichloro-1,3-benzothiazoleHCID 156142392,3-Difluoro-6-(trifluoromethyl)anilineHCID 178505734HCID 178505734, compound

Product 1

HCID 675207732-Chloro-7-fluoro-4-trifluoromethyl-1,3-benzothiazole

Conditions

Temperature
90 °C

Procedure

The title compound was prepared from 2,3-difluoro-6-trifluoromethylaniline via 2-mercapto-7-fluoro-4-trifluoromethyl-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 90° C. for 4 h.

Sources & evidence

ORD record
ord-92ed05d788bf43e0a77a50ac988de0b7
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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