2,3-Difluoroaniline → 4,5-Difluoro-1,3-benzothiazol-2-amine

HRID 1926421Notes

Reaction equation

HRID 1926421 reaction equation
[NH2:1][C:2]1[S:3]C2C(F)=CC=CC=2N=1.[F:12][C:13]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:14]=1[NH2:15].FC1C(F)=CC=C(F)C=1N>>[NH2:1][C:2]1[S:3][C:16]2[CH:17]=[CH:18][C:19]([F:20])=[C:13]([F:12])[C:14]=2[N:15]=1

Participants

4

Reactant 3

HCID 782782,3-DifluoroanilineHCID 5222832,3,6-TrifluoroanilineHCID 148922457-Fluoro-1,3-benzothiazol-2-amine

Product 1

HCID 610754024,5-Difluoro-1,3-benzothiazol-2-amine

Procedure

The title compound was prepared following the route for 2-amino-7-fluoro-1,3-benzothiazole from 2,3-difluoroaniline, starting from 2,3,6-trifluoroaniline and conducting the first step at 100° C. for 4 h.

Workup

  1. customat 100° C.
  2. customfor 4 h.

Sources & evidence

ORD record
ord-8ea0373e944a471a94fed8910cd71d72
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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