反应详情

Following the procedure for 3-(7-fluoro-4-trifluoromethylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, using 2-iodo-1,3-benzothiazole-7-carbonitrile and conducting the Suzuki coupling at 55° C. for 3 h, the title compound was obtained as a brown solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.31 (m, 4H), 3.05-3.18 (m, 2H), 3.37-3.44 (m, 2H), 3.77 (brs, 2H), 4.45-4.54 (m, 1H), 7.51 (brs, 1H), 7.75-7.78 (m, 1H), 8.07 (d, J=7.2 Hz, 1H), 8.10 (s, 1H), 8.44-8.48 (m, 3H), 8.58 (brs, 1H), 8.88 (brs, 1H), 9.10 (brs, 1H). MS(ES+): m/z=402.13 (100) [MH+]. HPLC: tR=2.06 min (ZQ3, polar—5 min).

1. customat 55° C.
2. customfor 3 h