2-Chloro-4-methoxy-1,3-benzothiazole → HCID 67521852, compound

Participants

Reaction Steps

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-4-methoxy-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.09-2.30 (m, 4H), 3.05-3.19 (m, 2H), 3.42 (d, J=13.2 Hz, 2H), 4.01 (s, 3H), 4.46-4.56 (m, 1H), 7.14 (d, J=8.0 Hz, 1H), 7.46 (t, J=8.07 Hz, 1H), 7.70 (d, J=8.0 Hz, 1H), 8.03 (s, 1H), 8.25 (br. s., 1H), 8.36 (s, 1H), 8.49 (d, J=2.2 Hz, 1H). MS (ES+): m/z=407.14 [MH+]. HPLC: tR=1.93 min (ZQ2, polar—5 min).

Provenance & Evidence