反应详情

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-chloro-6-trifluoromethyl-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.11-2.30 (m, 4H), 3.11 (q, J=10.8 Hz, 2H), 3.41 (d, J=12.4 Hz, 2H), 4.47-4.58 (m, 1H), 7.92 (d, J=8.4 Hz, 1H), 8.08 (s, 1H), 8.32 (d, J=8.4 Hz, 1H), 8.43 (br. s., 2H), 8.58 (br. s., 1H), 8.76 (br. s., 1H). MS (ES+): m/z=445.08 [MH+]. HPLC: tR=2.25 min (ZQ2, polar—5 min).