HCID 67520656, compound → HCID 67520861, compound

Participants

Reaction Steps

Following the procedure for 3-(7-fluoro-4-trifluoromethylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, using 2-iodo-7-methyl-4-trifluoromethyl-1,3-benzothiazole and conducting the Suzuki coupling at 55° C. for 3 h, the title compound was obtained as a yellow-green solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.31 (m, 4H), 2.70 (s, 3H), 3.07-3.18 (m, 2H), 3.37-3.44 (m, 2H), 3.54 (brs, 2H), 4.47-4.56 (m, 1H), 7.53 (d, J=9.2 Hz, 1H), 7.88 (d, J=7.6 Hz, 1H), 8.08 (d, J=0.8 Hz, 1H), 8.41-8.46 (m, 2H), 8.57 (d, J=2.4 Hz, 1H), 8.76 (brs, 1H), 8.96 (brs, 1H), MS(ES+): m/z=459.09 (100) [MH+]. HPLC: tR=2.32 min (ZQ3, polar—5 min).

Provenance & Evidence