HCID 67520656, compound → HCID 67520651, compound

Participants

Reaction Steps

Following the procedure for 3-(7-fluoro-4-trifluoromethylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, using 2-iodo-5-trifluoromethoxy-1,3-benzothiazole and conducting the Suzuki coupling at 50° C. for 2 h, the title compound was obtained as a yellow solid. 1H NMR (400 MHz, CD3OD): δ=8.84 (d, J=1.6 Hz, 1H), 8.43 (s, 1H), 8.42 (d, J=2.0 Hz, 1H), 8.24 (d, J=8.4 Hz, 1H), 8.15 (m, 1H), 8.09 (s, 1H), 7.55 (m, 1H), 4.68 (m, 1H), 3.61-3.68 (m, 2H), 3.28-3.30 (m, 2H), 2.35-2.42 (m, 4H). MS(ES+): m/z=461.15 [MH+]. HPLC: tR=1.84 min (polar—5 min, ZQ3).

Provenance & Evidence