HCID 67520656, compound → HCID 67521393, compound

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Reaction Steps

Following the procedure for 3-(7-fluoro-4-trifluoromethylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, using 7-chloro-2-iodo-4-trifluoromethyl-1,3-benzothiazole and conducting the Suzuki coupling at 70° C. for 3 h, the title compound was obtained as a yellow-green solid. 1H NMR (400 MHz, DMSO-d6): δ=2.14-2.36 (m, 4H), 3.05-3.18 (m, 2H), 3.37-3.44 (m, 2H), 4.01 (brs, 2H), 4.45-4.56 (m, 1H), 7.82 (d, J=8.4 Hz, 1H), 7.99 (d, J=8.4 Hz, 1H), 8.11 (s, 1H), 8.25 (brs, 1H), 8.46 (s, 1H), 8.47 (d, J=2.0 Hz, 1H), 8.62 (d, J=2.4 Hz, 1H), 8.86 (brs, 1H), 9.06 (brs, 1H). MS(ES+): m/z=478.98/481.00 (100/76) [MH+]. HPLC: tR=2.37 min (ZQ3, polar—5 min).

Provenance & Evidence