HCID 67520656, compound → HCID 67520752, compound

Participants

Reaction Steps

Following the procedure for 3-(7-fluoro-4-trifluoromethylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, using 2-iodo-4-trifluoromethoxy-1,3-benzothiazole and conducting the Suzuki coupling at 50° C. for 12 h, the title compound was obtained as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=9.12-9.03 (brm, 1H), 8.94-8.82 (brm, 1H), 8.57 (d, J=2.0 Hz, 1H), 8.41 (brs, 2H), 8.34 (very brs, 2H), 8.26 (dd, J=2.2, 6.6 Hz, 1H), 8.07 (s, 1H), 7.66-7.60 (m, 2H), 4.57-4.48 (mc, 1H), 3.41 (brd, J=12.8 Hz, 2H), 3.11 (brq, J=11.2 Hz, 2H), 2.30-2.12 (m, 4H). MS(ES+): m/z=461.06 (74) [MH+], 378.06 (100) [MH+-piperidine]. HPLC: tR=2.27 min (polar—5 min, ZQ2).

Provenance & Evidence