Hydrochloric Acid → HCID 44159051, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-{4-[6-amino-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-pyrazol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester (BB8) (30 mg, 0.064 mmol), 2-iodo-4,5,6,7-tetrahydrobenzothiazole (20 mg, 0.077 mmol), potassium carbonate (26 mg, 0.19 mmol), and Pd(PPh3)4 (7.4 mg, 0.0064 mmol) in DME (1.5 mL) and H2O (0.5 mL) was evacuated and refilled with N2 (3×). It was then heated at 100° C. for 30 min in the microwave reactor. The mixture was diluted with EtOAc (30 mL), washed with brine (10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (Hex.:EtOAc=30:70→15:85) to give a yellow solid. This material was dissolved in DCM (2 mL) and treated with IM HCl in diethyl ether (3 mL). The resulting mixture was stirred at room temperature for 3 h. The title compound was collected by filtration as a yellow solid, washed with DCM, and dried in vacuo. 1H NMR (DMSO-d6, 400 MHz): δ=1.82-1.88 (m, 4H), 2.14-2.23 (m, 4H), 2.81-2.87 (m, 4H), 3.35-3.40 (m, 2H), 4.55 (mc, 1H), 8.09 (s, 1H), 8.44 (d, J=2.0 Hz, 1H), 8.47 (s, 1H), 8.50 (d, J=2.0 Hz, 1H). MS (ES+): m/z=381.17 [MH+].

Provenance & Evidence